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Chemotherapy was potentiated by E7449 and one agent experienced significant antitumor action in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, most likely by TNKS inhibition. In keeping with this possibility, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilizat